A decrease in lung cancer mortality following the introduction of low-dose chest CT screening in Hitachi, Japan. Reduced lung-cancer mortality with low-dose computed tomographic screening. National Lung Screening Trial Research Team Aberle DR et al. In addition, weighted κ statistics were used to determine the agreement between Lung-RADS classification obtained with each method and the reference standard generated from standard-dose CT evaluated by two radiologists who were not included in the image analysis session. To compare nodule detection capability of the three methods, consensus for performances was rated by using jackknife free-response receiver operating characteristic analysis, and sensitivity was compared by means of the McNemar test. All nodules were then evaluated in terms of their Lung-RADS classification using each method. Probability of nodule presence was assessed for all methods with a five-point visual scoring system by two board-certified radiologists. In this prospective study, standard- and low-dose chest CT (270 mA and 60 mA, respectively) and MRI with UTE were used to examine consecutive participants enrolled between January 2017 and December 2020 who met American College of Radiology Appropriateness Criteria for lung cancer screening with low-dose CT.
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